Previously, differentials of feline facial pruritus were discussed to include ectoparasites such as flea allergy, otodectes, Notoedres and cheyletiella, food allergy, atopy including possible food storage mite allergy and demodicosis. Less common differentials include infections such as dermatophytosis, viral, and bacterial pyoderma, Malassezia dermatitis, Pemphigus foliaceus (PF) and idiopathic facial dermatitis of the Persian cat. Clinically, many of these diseases appear similar including Pemphigus foliaceus and bacterial pyoderma which can be difficult to differentiate both clinically and histopathologically.