When performing surgery in ferrets, rabbits, guinea pigs and rodents one must take into consideration the small size, rapid metabolic rate and unique physiology of these species. Perioperative supportive care including fluid therapy, prevention of hypothermia, and pain management are essential in ensuring the successful outcome of these small surgical patients. In general, ferrets are very hardy surgical patients and can withstand a high degree of surgical trauma, whereas rabbits and guinea pigs are sensitive surgical patients that require minimal tissue handling and close anesthetic and post operative monitoring.