Medical device for periodontal tissue repair launches in US market

A prescription medical device for promoting natural periodontal tissue repair in dogs has been launched in the US by PRN Pharmacal. The device, ReGum Vet, is a scaffold that fills and supports canine periodontal defects, providing a framework for tissue repair.¹

The product was developed using patented CellFoam technology by BioChange in Israel. The biodegradable 3D foam is composed of enzymatically cross-linked gelatin that promotes periodontal tissue repair.¹

Image courtesy of PRN Pharmacal

“For the first time, practitioners have a targeted product for dogs with naturally occurring periodontitis that is easy to apply and actively supports the body’s own tissue-repair process,” Amanda Crouthamel, DVM, technical services veterinarian for PRN, said in a news release.¹ “We’re excited to partner with veterinary teams nationwide to raise the standard of care for advanced periodontal disease in dogs.”

ReGum Vet is designed to be placed into the periodontal defect, and allow space for healthy tissue growth. According to PRN Pharmacal, the device is safe, nontoxic, and biodegrades.¹

A study of 9 canine patients with periodontitis and 22 affected teeth, published in Frontiers in Veterinary Science, found ReGum Vet “significantly improved” outcomes when added to open periodontal therapy. These investigators indicated that “the use of this implant can be recommended in addition to open periodontal therapy in dogs with advanced periodontitis, considering the careful selection of the patients and teeth that will truly benefit from the treatment.”²

The device was first made available in 2023, in Israel, and has subsequently been made available in South Korea and in Europe. It is available in both a conic shape for deep holes, and a flat square shape to treat side pockets.¹

ReGumVet can be integrated into canine periodontitis procedures, requiring only a few steps for veterinarians, according to PRN Pharmacal. The steps to apply the device are as follows, with additional instructions available with the product¹:

1. Dip the 3D dry foam in sterile saline or sterile Lactated Ringer’s Solution to reconstitute elasticity or use dry.
2. Trim ReGumVet to fit the surgical site.
3. Insert the product into the surgical site and position as needed.
4. Close the surgical site with sutures.

“Veterinarians implementing dental radiography often find they are extracting more teeth than before the utilization of intraoral radiography,” Jennifer Mathis, DVM, CVPP, DAVDC, owner of Family Pet Veterinary Center and Animal Dentistry Referral Services, both in West Des Moines and Norwalk, Iowa, said in the release.¹ “ReGum Vet can be used to change the outcome. We can stabilize and reverse specific sites of hidden bone loss when there is still gum tissue present, enabling us to preserve more teeth.”

Studies have shown that 80%-90% of dogs older than 3 years have a component of periodontal disease, making it one of the most common health issues in veterinary medicine. Smaller breeds have a higher risk for periodontal disease, and the rate of incidence increases with age.³

According to PRN Pharmacal, signs of the disease range from reversible gingivitis to progressive stages requiring more aggressive treatment. Left untreated, periodontal disease can affect other areas of the body and increase a dog’s risk of cardiovascular, kidney and liver diseases.¹

References

1. PRN Pharmacal launches ReGum Vet to US veterinarians. News release. PRN Pharmacal. July 22, 2025.
2. Gawor JP, Strøm P, Nemec A. Treatment of naturally occurring periodontitis in dogs with a new bio-absorbable regenerative matrix. Front Vet Sci. June 20, 2022. Accessed August 5, 2025. https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.916171/full
3. Periodontal disease. Cornell University College of Veterinary Medicine, Richard P. Riney Canine Health Center. Accessed August 5, 2025. https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/health-topics/canine-health-information/periodontal-disease#:~:text=Periodontal%20disease%20is%20one%20of%20the%20most,breeds%2C%20and%20the%20incidence%20increases%20with%20age.