Agave plant triggers serious reaction in dog

Kathi Furnas of Marana, Arizona, lets her dog Kiki out every morning to ‘take care of business’ while it is still dark out. However, one morning, instead of coming back relieved, Kiki came back with her face soaking wet. It turns out that during her time outside, Kiki dug up and ate parts of her owner’s agave plant.

Furnas believed that she chased some other type of animal into the plant and started to chew away. Several hours after this, Kiki's face began to swell and her owners could tell she was in pain, so they wiped her down with a wet cloth. That night, since Kiki was still in pain, they brought her to the hospital.

Kiki was brought to the emergency room after ingesting an agave plant, whcih caused her face to swell and show signs of being in pain (Image courtesy of Pet Poison Helpline)

Furnas brought Kiki to the Veterinary Emergency Group (VEG) in Oro Valley, Arizona where a medical team had Furnas call Pet Poison Helpline. The medical team and PPH worked together to assess Kiki physically and create a treatment plan based on her specific situation.

“Kiki likely had a severe reaction to the sap of an agave plant, which contains many different irritants,” explained Renee Schmid, DVM, DABT, DABVT, a senior veterinary toxicologist and director of Veterinary Medicine at Pet Poison Helpline, in an organizational release.¹ “She developed hives, significant facial swelling, and redness and skin sloughing. In large grazing animals, liver failure can occur, but in dogs we only expect skin irritation and GI upset.”

The team at VEG placed Kiki under sedation so they could scrub her face and then administered antibiotics and pain medication. Because of the reaction Kiki had to the plant material, the veterinarians at Pet Poison Helpline recommended that Kiki be bathed to remove any of the remaining sap and given an antihistamine, plus a short-acting steroid to help reduce the severity of her reaction.¹ The team also learned that Kiki was in pain from the swelling as well as the irritation that developed from her chewing on the sharp spines of the leaves, so she was having trouble eating.¹ The team administered analgesics and gave her an appetite stimulant.

Kiki is now officially back in full health and continues to chase creatures in her yard but has not gone near the agave plant since the incident. Furnas also told Pet Poison Helpline that they now take a flashlight with them when they let Kiki out in the dark.

While she was with Kiki at the hospital, Furnas witnessed some pet owners struggling to make medical decisions for the pets because of the treatment's cost. Wanting to help, Furnas asked the staff if there was anything they could do.

“We saw a young couple talking to the hospital staff, and they were trying to figure out how to pay for their pet’s treatment,” Furnas shared.¹ “We asked the hospital if we could help, and they have a fund people can donate to that helps offset some of the costs. The money stays local and helps local pets. We set up a small donation every month.”

This installment of Toxin Tails was released in recognition of National Tequila Day which was July 24^th. Even though Kiki did not ingest any actual tequila, the team at Pet Poison Helpline wants to share KiKi’s story and remind clients that alcohol is very dangerous to pets. It can cause serious drops in blood sugar, blood pressure, and body temperature. Pets that become severely intoxicated can also potentially experience respiratory failure and seizures. Veterinary teams should instruct clients that if their pet was to ever ingest any alcohol, to call their veterinary hospital or Pet Poison Helpline immediately.

Reference

1. A Severely Swollen Face with No Tequila High. News release. Pet Poison Helpline. July 23, 2025. Accessed July 28, 2025. https://prnmedia.prnewswire.com/news-releases/a-severely-swollen-face-with-no-tequila-high-302510991.html