Dermatology

Alert the President! Study calls into question claims that some dogs are allergen-free

This condition affects dogs of any age or breed, although German shepherds are predisposed. It affects the mucocutaneous junctions (MCJs) of the nose and lips most frequently, but other MCJs can also be affected. This is a surface bacterial infection (usually S. pseudintermedius) wherein there is a "standoff" between the bacteria and the immune system at the MCJ.

In the field of veterinary medicine we see a constant search for newer, more effective, and convenient but inexpensive drugs with lesser side effects. Not only new drugs are interesting, but old drugs are occasionally rediscovered for new indications.

Bacterial pyoderma is more common in the dog than any other mammalian species. Currently Staphylococcus virulence factors such as protein A, leukocidin, hemolysins, epidermolytic toxin have not been shown to be to play a role in canine pyoderma as opposed to humans with Staphylococcus aureus infections.

PF is the most common immune-mediated skin disease of the cat. It often begins on the face and pinnae, but also usually involves the foot pads and claw beds. Crusts and pustules on the face and pinnae, hyperkeratotic footpads, a purulent to caseous discharge with crusting around the nail beds, and crusting of the nipples are all common findings.

Vasculitis is characterized by an aberrant immune response directed toward blood vessels. Histologically there is an inflammatory response involving and destroying blood vessels leading to ischemic changes (see histopathology). A vasculopathy is a disease process in which tissue changes are consistent with ischemia but histologically vasculitis can't be identified.

The skin is the largest organ of the body and, in the view of many practitioners, it often accounts for the largest number of headaches. One would expect that since the skin is so easy to visualize, a diagnosis should be an easy task when compared with other, more hidden body organs. The problem is that many skin conditions have the same clinical presentation.

Itraconazole (Sporonax ?-Janssen Pharmaceuticals- 100 capsules and 10 mg/ml oral solution)) is a member of the azole family of antifungal agents. Imidazoles (Imidazole family (thiabendazole, clotrimazole, ketaconazole, miconazole and enilconazole) and triazoles (itraconazole and fluconazole) make up this family of drugs.

Zinc responsive dermatosis is a nutritional skin disease that can be categorized as syndromes I or II. Syndrome I is a disease primarily seen in Siberian huskies and Malamutes. Lesions develop in these breeds despite having adequate zinc in their diets and most commonly occur in young dogs (1-3 years of age).

Protocols are useful in helping to diagnose and treated many different disorders. Part of any good protocol should be a minimum data base (MDB). In addition to signalment, history, etc in veterinary dermatology laboratory testing should be a component of this data base.

In the normal dog fasting does not usually result in hypoglycemia. Therefore a serum glucose concentration < 60 mg/dl is almost always due to either organic disease or to laboratory error. In an animal with normal glucose homeostasis, insulin secretion is stimulated when the blood glucose is > 110 mg/dl; insulin secretion is depressed and secretion of hormones that oppose insulin (epinephrine, glucagon, cortisol, growth hormone) is stimulated when the blood glucose falls below < 60 mg/dl.

It is important to understand that ear disease is only a symptom (no more specific than "pruritus"). As Dr Flemming Kristensen stated "A patient showing ear problems is a dermatology case until proven otherwise". It is appropriate therefore to approach the diagnosis of ear disease just as you would for any other skin disease.

Behavior and medicine (or physiology) are not mutually exclusive; there is a complex interaction between the two. Studies published recently in the British Journal of Dermatology concluded that human patients subjected to brief psychological stress (PS) developed an increase in Psoriasis Area and Severity Index (PASI) and itch 4 weeks later(Verhoeven, 2009).

Topical therapy is an important symptomatic and complimentary treatment option in the management of various skin diseases. Canine skin is often more sensitive than is human skin due to anatomical and physiological differences, including differences in the thickness of the stratum corneum, skin pH and hair follicle density which can facilitate cutaneous penetration of active ingredients.

Once you have finished interviewing the witnesses, the next step is to collect the evidence. A minimum database ("derm–due-diligence") for any pruritic pet should include skin scrapings, close examination for external parasites (fleas, ticks, and lice), acetate tape tests, cytology and possibly coat brushings.

Canine pyoderma is a common secondary problem, a leading cause of antibiotic use in dogs, and an often frustrating problem for vets and pet owners alike. Unlike many other types of infections, skin infections are often recurrent. This frequently leads to an ongoing cycle of being on and off of antibiotics.

Pustules, crusts and epidermal collarettes are superficial skin lesions which are often seen in association with superficial pyoderma. Although in such situations a pyoderma is the most likely diagnosis and antibiotic therapy is justified, other diseases should be considered, especially after poor response to initial therapy.

Diabetes mellitus (DM) is a common endocrine disease in dogs and cats characterized by an absolute or relative deficiency of insulin. This results in a decreased ability of cells to take up and utilize not only glucose, but also amino acids, fatty acids, and electrolytes. In addition the lack of insulin results in increased gluconeogenesis, glycogenolysis, lipolysis, ketogenesis, and protein catabolism.

Hypothyroidism results in decreased production of the thyroid hormones thyroxine (T4) and triiodothyronine (T3) from the thyroid gland. At least 95% of cases of canine hypothyroidism are believed to be due to acquired primary hypothyroidism. Destruction of the thyroid gland can result from lymphocytic thyroiditis, idiopathic thyroid atrophy, or rarely neoplastic invasion.

Malassezia is a genus of lipophilic yeast found as a commensal of the skin and mucosal surfaces that may cause skin disease in a variety of mammalian species. In normal dogs these organisms are present in very small numbers on the skin (fold areas-lip, vulvar, axillae, interdigital), oral and anal mucosal surfaces, in the ear canals and anal sacs. In contrast to Candida, MD is not associated w/recent antibiotic administration, in fact, there appears to be a symbiotic relationship between the surface staphylococcal organisms and the yeast.

Fleas are still the most common cause for parasite induced pruritic skin problems in many geographical regions. Since the nineteen's many different drugs and preventative have been introduced to prevent and to treat flea infestation, and certainly the occurrence of severe widespread infestations have declined. However, the lack of pet owner compliance and neglect of addressing environmental flea ainfestation are probably the most common causes for a chronic recurring flea problem.

Skin and ear problems are very common reasons for dogs and cats being presented to a veterinarian. These animals can suffer from many different skin diseases with a wide range of underlying causes. Because the skin has a limited range to react to the different insults a straight-forward diagnosis is commonly not possible, especially in patients with chronic skin diseases.

Approximately 80 to 85% of cases of hyperadrenocorticism in dogs are due to pituitary dependent hyperadrenocorticism (PDH), with the remainder due to an adrenocortical tumor (AT). Cortisol is the most common secretory product of the adrenal gland in hyperadrenocorticism.

The diagnosis of ANY skin disease is based on detailed history taking, clinical findings (identification of primary lesions, distribution of lesions), laboratory testing and therapeutic trials. For autoimmune skin diseases (AISD) the most beneficial laboratory procedure is histopathologic evaluation.

In order to understand when and how to culture, it may be useful to first understand a bit about the etiology and pathophysiology regarding pyoderma: