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Nyssa J. Reine, DVM, DACVIM (small animal internal medicine)

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Practical Matters: Urine cortisol:creatinine ratio-the most useful normal test around

Definitively diagnosing canine hyperadrenocorticism (Cushing's disease) can be exceptionally difficult because nonadrenal illness can affect the test results. However, I think that the urine cortisol:creatinine ratio (UC:Cr) serves an invaluable role in ruling out canine Cushing's disease since a dog with a normal UC:Cr almost assuredly does not have Cushing's disease.

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