Case 12

Your plan for Wyatt at this time is to treat empirically for sarcoptic mange and use response to therapy as a diagnostic tool. The most common treatment options include oral ivermectin (extralabel use) and topical products such as imidacloprid-moxidectin (extralabel use) or selamectin. You also recommend concurrently ruling out food allergy dermatitis with a hypoallergenic diet trial, but because the owners have a new baby and less time to devote to the monitoring required for this option, they choose to wait on this diagnostic step.

QUESTION 7

Which statement about ivermectin is false?

a) Ivermectin is photolabile and should be protected from light.

b) Ivermectin is not FDA-approved as an ectoparasiticide and endoparasiticide in dogs and cats.

c) Ivermectin toxicosis is more likely to occur in collies, Shetland sheepdogs, and many other herding breeds and occurs because of a recessive mutation in the multidrug resistance gene (MDR1 gene).

d) Signs of ivermectin toxicosis in dogs include mydriasis, tremors, ataxia, and depression; death can be seen.

e) Ivermectin should not be used concurrently with azole fungal medications and high-dose ivermectin should not be used concurrently with spinosad because of an increased likelihood of ivermectin toxicosis.

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