Food Animals

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The design of antimicrobial regimens is addressed in the next section in these proceedings ("Antimicrobial Therapy: Regimen Design"), but the concepts within regimen design related to determining the concentration of drug required to inhibit growth of bacterial pathogens deserve a more thorough discussion. Antimicrobial susceptibility testing must not be viewed as a black box into which a veterinarian places a clinical sample of an infected site and receives a "yes" or "no" from the diagnostic laboratory.

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Bovine respiratory disease complex includes bacterial components, which cause the classic clinical signs of lethargy, depression, and fever, with variable nasal discharge, cough, or other signs. This bacterial component of BRD (most commonly Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis) may be treated with antimicrobial drugs designed to kill or inhibit the growth of the pathogenic bacteria.

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In this session we will take an evidence-based medicine approach to ancillary therapy of bovine respiratory disease. The literature reviewed here is not presented as being all-inclusive, but rather as a summary of many commonly cited articles on these subjects. The citations are primarily peer reviewed, but some are from freedom of information (FOI) summaries and a few are proceedings papers or abstracts.

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Recently, the use of antimicrobials in food animals has been scrutinized by the general public, by federal legislators, and by public health organizations. Some of these concerns relate to the use of antimicrobials as growth promotants, while some relate to the use of antimicrobials in food animals in general.