How can a dog's weight affect insulin therapy?
“Although many diabetics lose weight as a result of the disease, some are still obese when treatment is initiated. Obesity may blunt the response to exogenous insulin and make regulation more difficult. An appropriate weight loss program should be started immediately, with the goal of reaching an optimal body condition score within four months.”
-Audrey K. Cook, BVM&S, MRCVS, DACVIM, DECVIM