How Take C.H.A.R.G.E. fosters a One Health approach
Along with advancing canine cancer research, Take C.H.A.R.G.E. can help advance human oncology research. According to Fossum, there are flaws involving the standard for research approaches, including using mice as our modality to study the efficacy treatments before we move into human clinical trials. “Because our data is usually mouse to man, it doesn’t work,” she said. However, dogs are more predictive models as they suffer from similar cancers to humans and we use similar drugs, so data from the registry is of multifaceted value.
An additional benefit Fossum highlighted was, “The other thing [the registry] is going to do is as we survey the data, because dogs live in the same environment, oftentimes they drink the same water, they eat the same food, we really think we may get early signals of areas where maybe there's a higher cancer rate than there should be because of some environmental factor. And the dogs will probably show that increased incidence of cancer several years before people would.” Thus, this indicates hazardous geographical areas to avoid to potentially save humans and their dog counterparts.