Possibly. Surgical removal and histologic examination of an adrenal mass is the ideal plan, but not every dog is a suitable surgical candidate and not every owner elects surgery. A discussion with the owner about why surgery is needed or recommended and whether the pet is a good candidate for surgery will need to occur. If surgery is not an option, treatment with mitotane can be considered in an effort to shrink the mass. These patients typically require higher starting doses (50 to 75 mg/kg/day) until cortisol concentrations are within the target range. Trilostane can also be considered as palliative therapy but will not affect the tumor.
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