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Study reveals Zymox Otic Plus is beneficial and effective


Findings demonstrate this otitis externa treatment can potentially serve as alternative to antibiotics

ThamKC / stock.adobe.com

ThamKC / stock.adobe.com

PKB Animal Health, a company focusing on enzyme-based dermatology and oral care products for animals, announced1 the Polish Journal of Veterinary Sciences has published findings2 based on a recent study investigating the effects of Zymox Otic Plus on canine otitis externa and removal of biofilms. The study evaluated the in vivo and in vitro efficacy, revealing that Zymox Otic Plus is “effective and beneficial” for canine otitis externa management.

Otitis externa is the most common disorder of the ear canal in dogs.3 However, antibiotic resistance presents a major challenge to its treatment and it is believed that bacteria and yeast produce biofilm structures that lead to persistent conditions that are not responsive to traditional antibiotic therapeutics. On the other hand, Zymox Otic Plus features a combination of enzymes including the biofilm-degrading enzymes mutanase and dextranase. This study’s conclusion displays that Zymox Otic Plus may serve as an effective alternative to antibiotics.

Other studies highlighting Zymox’s efficacy have been published in the International Journal of Applied Veterinary Research on antibiofilm efficacy and a broad range of microorganisms, including Pseudomonas aeruginosa, Malassezia, and Methicillin-resistant Staphylococcus aureus (MRSA).


  1. Study concludes Enzyme-Based Advanced Formula ZYMOX® Otic Plus beneficial. News release. PKB Animal Health. January 30, 2023. Accessed January 30, 2023. https://www.prnewswire.com/news-releases/study-concludes-enzyme-based-advanced-formula-zymox-otic-plus-beneficial-301732814.html
  2. Fujimura M. Effects of an enzyme agent containing mutanase and dextranase for treatment of biofilms in bacteria- and yeast-infected canine otitis externa. Pol J Vet Sci. 2022 Sep;25(3):383-389. doi: 10.24425/pjvs.2022.142021.
  3. Moriello KA. Ear infections and otitis externa in dogs. Merck Veterinary Manual. June 2018. Updated October 2022. Accessed January 30, 2023. https://www.merckvetmanual.com/dog-owners/ear-disorders-of-dogs/ear-infections-and-otitis-externa-in-dogs
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