• DVM360_Conference_Charlotte,NC_banner
  • ACVCACVC
  • DVM 360
  • Fetch DVM 360Fetch DVM 360
DVM 360
dvm360 | Veterinary News, Veterinarian Insights, Medicine, Pet Care
dvm360 | Veterinary News, Veterinarian Insights, Medicine, Pet Care
By Role
AssociatesOwnersPractice ManagerStudentsTechnicians
Subscriptions
dvm360 Newsletterdvm360 Magazine
News
All News
Association
Breaking News
Education
Equine
FDA
Law & Ethics
Market Trends
Medical
Politics
Products
Recalls
Regulatory
Media
dvm360 LIVE!™
Expert Interviews
The Vet Blast Podcast
Medical World News
Pet Connections
The Dilemma Live
Vet Perspectives™
Weekly Newscast
dvm360 Insights™
Publications
All Publications
dvm360
Firstline
Supplements
Vetted
Clinical
All Clinical
Anesthesia
Animal Welfare
Behavior
Cardiology
CBD in Pets
Dentistry
Dermatology
Diabetes
Emergency & Critical Care
Endocrinology
Equine Medicine
Exotic Animal Medicine
Feline Medicine
Gastroenterology
Imaging
Infectious Diseases
Integrative Medicine
Nutrition
Oncology
Ophthalmology
Orthopedics
Pain Management
Parasitology
Surgery
Toxicology
Urology & Nephrology
Virtual Care
Business
All Business
Business & Personal Finance
Hospital Design
Personnel Management
Practice Finances
Practice Operations
Wellbeing & Lifestyle
Continuing Education
Conferences
Conference Listing
Conference Proceedings
Upcoming dvm360 Conferences
Resources
CBD in Pets
CE Requirements by State
Contests
Partners
Spotlight Series
Team Meeting in a Box
Toolkit
Top Recommended Veterinary Products
Vet to Vet
Veterinary Heroes
  • Contact Us
  • Fetch DVM360 Conference
  • Terms and Conditions
  • Privacy
  • Do Not Sell My Information
  • About Us

© 2023 MJH Life Sciences and dvm360 | Veterinary News, Veterinarian Insights, Medicine, Pet Care. All rights reserved.

Advertisement
By Role
  • Associates
  • Owners
  • Practice Manager
  • Students
  • Technicians
Subscriptions
  • dvm360 Newsletter
  • dvm360 Magazine
  • Contact Us
  • Fetch DVM360 Conference
  • Terms and Conditions
  • Privacy
  • Do Not Sell My Information
  • About Us
  • MJHLS Brand Logo

© 2023 MJH Life Sciences™ and dvm360 | Veterinary News, Veterinarian Insights, Medicine, Pet Care. All rights reserved.

FDA Approves Pexion for Canine Noise Aversion

December 4, 2018
American Veterinarian Editorial Staff

The product has been available in Europe since 2013 for reducing seizure frequency in dogs with idiopathic epilepsy.

The FDA Center for Veterinary Medicine announced today that it has approved the Boehringer Ingelheim product Pexion (imepitoin tablets) as an effective treatment for noise aversion in dogs.

Pexion will be available by prescription only and is administered to the dog twice daily starting 2 days before an expected noise event and continued through the day of the event. The medication is available in 100- or 400-mg scored tablets and dosed according to weight.

According to the FDA, the efficacy of Pexion was evaluated in a study of client-owned dogs with a history of noise aversion behaviors. As part of the study, the dogs received either Pexion or a placebo twice daily for the 2 days preceding and on New Year’s Eve, when fireworks events were scheduled. The owners evaluated their dogs’ responses to the fireworks at 4 predetermined intervals and scored the level of 16 different behaviors. The overall score for the dogs that had taken Pexion was lower (ie, better) than the score for those that received the placebo.

The owners also evaluated the overall effect of treatment compared with previous New Year’s Eve fireworks experiences with the dogs. The owners of 66% of dogs given Pexion scored the overall treatment effect as excellent or good, compared with just 25% of dogs that received the placebo.

Advertisement

The most common adverse events (AEs) seen in the study were ataxia, increased appetite, lethargy, and vomiting. However, the owners of 3 of the 90 dogs that received Pexion in the efficacy trial reported that their dogs became aggressive, which included growling at a young child and lack of restraint or self-control toward other dogs.

The FDA warns that certain drugs used to reduce anxiety, such as Pexion, may lead to a lack of self-control of fear-based behaviors and thus result in an altered aggression level. The label information accompanying Pexion notes that pet owners should observe their dogs carefully during treatment. The agency recommends that veterinarians and owners of dogs that experience AEs should report them to the manufacturer, who is required to report them to the FDA. Veterinarians and pet owners can also file a report directly with the FDA by following the instructions at How to Report Animal Drug Side Effects and Product Problems.

Pexion was approved in Europe in 2013 as an alternative therapy to reduce seizure frequency in dogs with idiopathic epilepsy. An application for expanding the Pexion label in Europe for “the reduction of anxiety and fear associated with noise phobia in dogs” has been submitted.


Advertisement

Latest News

Learning more about AmeriVet

Announcing our 2023 Fetch and Directions in Veterinary Medicine continuing education schedule: Biggest event lineup to date

Dogs and staff at Seattle dog resort safely escape fire

Pet safety for this Super Bowl Sunday

View More Latest News
Advertisement