Sharon Gwaltney-Brant, DVM, PhD, DABVT, DABT

Dr. Sharon Gwaltney-Brant is vice president and medical director, ASPCA Animal Poison Control Center, and adjunct instructor in the Department of Veterinary Biosciences at the University of Illinois.

Articles by Sharon Gwaltney-Brant, DVM, PhD, DABVT, DABT

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Permethrin, a synthetic type I pyrethroid, is found in many flea and tick shampoos, dips, foggers, spot-ons, and sprays as well as many household and yard insecticide formulations. While permethrins have a relatively wide margin of safety in dogs, cats appear to be more sensitive to the toxicity of some concentrated pyrethroids, particularly permethrin.

Baits may come in the form of gels injected with a preloaded syringe or incorporated into a plastic housing. The bait may be mixed with food stuffs such as peanut butter, jelly, and bread crumbs to attract the insects. Most of the insecticides used in these products are of low mammalian toxicity; exposure to these insecticides cause little more than gagging or vomiting.

Aspirin (acetylsalicylic acid, ASA) is available as tablets, capsules, powders, effervescent tablets and oral liquid preparations. Aspirin reduces pain and inflammation by reducing prostaglandin and thromboxane synthesis through inhibition of cyclooxygenase. At very high dosages, aspirin and other salicylates uncouple oxidative phosphorylation, leading to decreased ATP production.

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Antidotes can be divided into three broad catagories: chemical antidotes, pharmacologic antidotes, and functional antidotes. Chemical antidotes act directly on the toxicant to make it less toxic and/or more readily excreted. Pharmacologic antidotes antagonize toxic agents at their receptor sites or through other macromolecules.

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