Leah A. Cohn, DVM, PhD, DACVIM

Department of Veterinary Medicine and Surgery

College of Veterinary Medicine

University of Missouri

Columbia, MO

Articles by Leah A. Cohn, DVM, PhD, DACVIM

Inhalant delivery of Aerosolized medication offers a number of theoretical benefits including an enormous absorptive surface area across a permeable membrane, a low enzyme environment that results in little drug degradation, avoidance of hepatic first-pass metabolism, and reproducible absorption kinetics.

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Cough is a common reason for dogs to be presented for veterinary care, and tracheal collapse is a common cause of chronic cough in dogs. The tracheal lumen remains open during both inspiration and expiration thanks to the support of cartilaginous rings.

Bacterial pneumonia encompasses a wide spectrum of disease from chronic to acute, unilobar or multilobar, and with clinical signs ranging from mild tachypnea or cough to rapidly progressive and fatal pulmonary infection. Cats are subject to bacterial pneumonia far less frequently than are dogs.

Respiratory disease is common in dogs, and can result in a constellation of clinical signs. These clinical signs range from those that are irritating to owners (e.g., nasal discharge, stridorous panting, chronic hacking cough) to those which are life-threatening and require immediate medical attention.

There are several ways to obtain samples from the airways and lower respiratory tract for cytologic evaluation and microbiologic culture. In general, samples should be handled quickly since respiratory epithelial cells degrade with some rapidity after retrieval, and samples should be handled gently to avoid damaging cell membranes.

Inhalant delivery of aerosolized medication offers a number of theoretical benefits including an enormous absorptive surface area across a permeable membrane, a low enzyme environment that results in little drug degradation, avoidance of hepatic first-pass metabolism, and reproducible absorption kinetics.

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