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At what dose can a carprofen overdose cause clinical signs?
“In otherwise healthy dogs, a review of the ASPCA APCC database historically indicated that fairly severe gastrointestinal signs may be seen at doses exceeding 20 mg/kg and that diuresis to prevent renal damage should be recommended at 40 mg/kg and above.”
-Donna Mensching, DVM, MS, DABVT, DABT, and Petra Volmer, MS, DVM, DABVT, DABT
From Toxicology Brief: Managing acute carprofen toxicosis in dogs and cats